A Clinically Superior Product
When Otolaryngologist-Head and Neck Surgeon, Dr. Scott A. Cordray, developed LAVI Sinus Wash and LAVI Nasal Spray (formerly branded Oasis), he first had to prove to himself that the products were clinically superior to what he, as a practicing physician, would otherwise prescribe. He did so through two preliminary clinical studies, followed by two Level 1 Double-Blind Clinical Studies conducted by one of the world’s foremost Otolaryngologists – Dr. Michael Friedman. The results were significant.
The only sinus products made using purified Dead Sea salts, LAVI is clinically proven more effective than other salt or seawater and as effective as nasal steroids without the risk of steroid-related complications. The science is in the anti-inflammatory effect attributable to the composition and concentration of minerals found only in Dead Sea salts that reduce swelling and congestion.
Sinus Wash Q&A What You Need to Know
The Clinical Proof
AS EFFECTIVE AS NASAL STEROIDS WITH SIGNIFICANT IMPROVEMENT OF SYMPTOMS.
Dead Sea salt irrigations vs saline irrigations with nasal steroids for symptomatic treatment of chronic rhinosinusitis: a randomized, prospective double-blind study. International Forum of Allergy & Rhinology Vol 2, No 3, May/June 2012 Pp 252:257.
OBJECTIVE: To compare the efficacy of nasal irrigations plus spray with Dead Sea salt (DSS) solution versus normal saline irrigation plus topical nasal steroid spray for the treatment of chronic sinonasal symptoms (CSS).
CONCLUSION: Treatment of chronic sinonasal symptoms with Dead Sea salt nasal irrigations and spray compared favorably to a regimen of normal saline and topical steroid spray and resulted in significant improvement of symptoms at four weeks without imposing the risk of established steroid-related complications.
DRAMATICALLY BETTER THAN OTHER SALINE.
A Randomized, Prospective, Double-Blind Study on the Efficacy of Dead Sea Salt Nasal Irrigations. Friedman, Ramakrishnan, Ninos. The Laryngoscope | 116 (June 2006, Pp 878-882).
OBJECTIVE: To compare nasal irrigation using mildly hypertonic Dead Sea salt (DSS) solution with hypertonic saline in the treatment of chronic rhinosinusitis and improvement of quality of life.
CONCLUSION: This study provides level 1 evidence on the superiority of Dead Sea salt over saline nasal irrigation for the treatment of chronic rhinosinusitis and only the group using Dead Sea salts showed improvement in quality of life based on the Standardized Rhinoconjunctivitis Quality of Life Questionnaire.
Other Clinical Studies
Use of Dead Sea salt solution for chronic rhinitis and rhinosinusitis. Operative Techniques in Otolaryngology (September 2006) | Howard L. Levine, MD; Scott Cordray, DO, Linda Miner, PhD.
Comparison of intranasal hypertonic Dead Sea saline spray and intranasal aqueous triamcinolone spray in seasonal allergic rhinitis. ENT-Ear, Nose & Throat Journal (July 2005, Pp 426-430) | Scott Cordray, DO, FAOCO; Jim B. Harjo, DO; Linda Miner, PhD.
Other Scientific ReferencesThe Dead Sea is well established as a place of natural healing and relief from dermatological, muscular, rheumatic , and respiratory ailments. The science behind this tradition is owed to the Dead Sea’s mineral composition and concentration levels - up to four times greater than any other body of water. These mineral elements are the same ones naturally occurring in the human body and are essential for maintaining optimum health: magnesium, calcium, potassium, sodium — and more than 70 others. Just a few of the studies that support this science include:
Nissenbaum, A., Minor and Trace Elements in Dead Sea Water, Chemical Geology, 19, 1977: 99-111
Keen JH: Intravenous Magnesium Sulfate for Acute Asthma. J Emerg Asthma 21, 1995: 44-46
Rolla G, Bucca C, et al, Reduction of Histamine-induced Bronchoconstriction by Magnesium in Asthmatic Subjects. Allergy 42, 1987: 186-188
Harari M, Barzillai R, Shani J., Magnesium in the Management of Asthma: Critical Review of Acute and Chronic Treatment, and Clinical Experience at the Dead Sea. Journal of Asthma 35(7), 1998:525-536
Levi-Schaffer F et al. Inhibition of Proliferation of Psoriatic and Healthy fibroblasts in Cell Culture by Selected Dead Sea Salts. Pharmacology 52, 1996: 321-328
Goldberg LH, Sagher F., Psoriasis Treatment at the Dead Sea. Department of Derm, Hadassah University Hospital – Israel.
Gruner S et al., Effect of Treatment with Salt from the Dead Sea on Epidermal Langerhans cells—A Clinical Study. Z Hautkr 1990 Dec; 65(12): 1146-51
Schempp CM, et al. Magnesium Ions Inhibit the Antigen-presenting Function of Human Epidermal Langerhans Cells in Vivo and in Vitro. Involvement of ATPase, HLA-DR, B7 molecules, and Cytokines. J Invest Dermatol. 2000 Oct; 115(4): 680-6
Schiffner R et al. Dead Sea Treatment – Principle for Outpatient use in Atopic Dermititis. Eur J Dermatol 2002; 12: 543-8
Greiner J, Diezel W. Inflammation-Inhibiting Effect of Magnesium Ions in Contact Eczema Reactions. Hautaezt 1990 Nov; 41(11): 602-5
Ludwig P, et al. Inhibition of Eicosanoid formation in Human Polymorphonuclear leukocytes by High Concentrations of Magnesium Ions. Biol Chem Hoppe Seyler 1995; 376: 739-744
Ponikau JU, et al. The Diagnosis and Incidence of Allergic Fungal Sinusitis. Mayo Clin Proc. 74, 1999: 877-884.
Chyrek-Borowska S, et al. The Relation Between Magnesium, Blood Histamine level and Eosinophilia in the Acute Stage of the Allergic Reactions in Humans. Archivium Immunologiae Et Theraapiae Experimentalis 26, 1978: 709-712
[Larbi KY, Gomperts BD, Complex pattern of inhibition by magnesium of exocytosis from permeabilised eosinophils. Cell Calcium 21(3) 1997: 213